Mucosal Administration of Completely Non-Replicative Vaccinia Virus Recombinant Dairen I strain Elicits Effective Mucosal and Systemic Immunity
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چکیده
منابع مشابه
Intrarectal vaccination with recombinant vaccinia virus expressing carcinoembronic antigen induces mucosal and systemic immunity and prevents progression of colorectal cancer.
The gastrointestinal mucosa contains an intact immune system that protects the host from pathogens and communicates with the systemic immune system. Absorptive epithelial cells in the mucosa give rise to malignant tumors although the interaction between tumor cells and the mucosal immune system is not well defined. The pathophysiology of colorectal cancer has been elucidated through studies of ...
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Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c. immunization with vaccinia induces cellular and antibody immunity to vaccinia only in systemic lymphoid tissue and not in mucosal sites, we hypothesized that the mucosal immune system remains naive to...
متن کاملMucosal immunity.
Food allergy is the manifestation of an abnormal immune response to antigen delivered by the oral route. Normal mucosal immune responses are generally associated with suppression of immunity. A normal mucosal immune response relies heavily on a number of factors: strong physical barriers, luminal digestion of potential antigens, selective antigen sampling sites, and unique T-cell subpopulations...
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BACKGROUND: It is important to understand the efficacy of immunoregulatory materials, herbal remedies or probiotics, in different parts of immune system following vaccination with different tropism. OBJECTIVES: Aim of this study was to evaluate the effect of Echinacea purpurea and a probiotic (protexin) on systemic and mucosal immune response in turkey. METHODS: A total of 288 1-day-old male tu...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2008
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.2008.02168.x